Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetChemokine receptor type 1 (CXCR1)
LigandBDBM50248083
Substrate/Competitorn/a
Meas. Tech.ChEMBL_566227
Ki 18±n/a nM
Citation Biju PTaveras AGYu YZheng JHipkin RWFossetta JFan XFine JLundell D 3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists. Bioorg Med Chem Lett 19:1434-7 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Chemokine receptor type 1 (CXCR1)
Name:Interleukin-8 receptors, CXCR1/CXCR2
Synonyms:C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:Enzyme
Mol. Mass.:39803.83
Organism:Homo sapiens (Human)
Description:P25024
Residue:350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50248083
n/a
NameBDBM50248083
Synonyms:(R)-(3-(4-(2,2-dimethyl-1-(5-methylfuran-2-yl)propylamino)-1,2,5-thiadiazol-3-ylamino)-2-hydroxyphenyl)(morpholino)methanone | CHEMBL518696
TypeSmall organic molecule
Emp. Form.C23H29N5O4S
Mol. Mass.471.572
SMILESCc1ccc(o1)[C@H](Nc1nsnc1Nc1cccc(C(=O)N2CCOCC2)c1O)C(C)(C)C |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: