| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM50248185 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_566617 (CHEMBL960143) |
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| IC50 | 720±n/a nM |
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| Citation |  Tasler, S; Müller, O; Wieber, T; Herz, T; Krauss, R; Totzke, F; Kubbutat, MH; Schächtele, C N-substituted 2'-(aminoaryl)benzothiazoles as kinase inhibitors: hit identification and scaffold hopping. Bioorg Med Chem Lett19:1349-56 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM50248185 |
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| n/a |
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| Name | BDBM50248185 |
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| Synonyms: | CHEMBL472946 | N-(4-(benzo[d]thiazol-2-yl)phenyl)thieno[3,2-d]pyrimidin-4-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C19H12N4S2 |
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| Mol. Mass. | 360.455 |
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| SMILES | N(c1ccc(cc1)-c1nc2ccccc2s1)c1ncnc2ccsc12 |
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| Structure | 
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