| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 2 |
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| Ligand | BDBM50257636 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_562362 (CHEMBL1017976) |
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| IC50 | 39.8±n/a nM |
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| Citation |  Jahangir, A; Alam, M; Carter, DS; Dillon, MP; Bois, DJ; Ford, AP; Gever, JR; Lin, C; Wagner, PJ; Zhai, Y; Zira, J Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett19:1632-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 2 |
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| Name: | P2X purinoceptor 2 |
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| Synonyms: | ATP receptor | P2RX2 | P2RX2_HUMAN | P2X2 | Purinergic receptor | PurinergicP2X2/3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51765.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PurinergicP2X2/3 0 HUMAN::Q9UBL9 |
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| Residue: | 471 |
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| Sequence: | MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYV
FIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQ
TQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVED
GASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFK
LGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYN
FRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCD
WILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSG
QEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
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| BDBM50257636 |
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| n/a |
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| Name | BDBM50257636 |
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| Synonyms: | 5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine | CHEMBL526307 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17IN4O2 |
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| Mol. Mass. | 400.2149 |
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| SMILES | COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I |
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| Structure | 
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