| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 1 |
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| Ligand | BDBM50257829 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_562363 (CHEMBL1017977) |
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| IC50 | >10000±n/a nM |
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| Citation |  Jahangir, A; Alam, M; Carter, DS; Dillon, MP; Bois, DJ; Ford, AP; Gever, JR; Lin, C; Wagner, PJ; Zhai, Y; Zira, J Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett19:1632-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 1 |
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| Name: | P2X purinoceptor 1 |
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| Synonyms: | ATP receptor | P2RX1 | P2RX1_HUMAN | P2X1 | Purinergic receptor | Purinergic, P2X |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44992.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purinergic, P2X 0 HUMAN::P51575 |
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| Residue: | 399 |
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| Sequence: | MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSG
LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEH
PEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLR
EAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESG
QNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVEN
GTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKR
HYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS
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| BDBM50257829 |
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| n/a |
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| Name | BDBM50257829 |
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| Synonyms: | 2-(4-amino-5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidin-2-ylamino)propane-1,3-diol | CHEMBL494161 | Ro-51 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H23IN4O4 |
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| Mol. Mass. | 474.2934 |
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| SMILES | COc1cc(C(C)C)c(Oc2cnc(NC(CO)CO)nc2N)cc1I |
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| Structure | 
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