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TargetP2X purinoceptor 4
LigandBDBM50257829
Substrate/Competitorn/a
Meas. Tech.ChEMBL_562365 (CHEMBL1017979)
IC50>10000±n/a nM
Citation Jahangir, AAlam, MCarter, DSDillon, MPBois, DJFord, APGever, JRLin, CWagner, PJZhai, YZira, J Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett19:1632-5 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
P2X purinoceptor 4
Name:P2X purinoceptor 4
Synonyms:ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4
Type:Enzyme Catalytic Domain
Mol. Mass.:43374.70
Organism:Homo sapiens (Human)
Description:Purinergic, P2X4 0 HUMAN::Q99571
Residue:388
Sequence:
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV
VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP
DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK
AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG
HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY
RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC
MKKRLYYREKKYKYVEDYEQGLASELDQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50257829
n/a
NameBDBM50257829
Synonyms:2-(4-amino-5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidin-2-ylamino)propane-1,3-diol | CHEMBL494161 | Ro-51
TypeSmall organic molecule
Emp. Form.C17H23IN4O4
Mol. Mass.474.2934
SMILESCOc1cc(C(C)C)c(Oc2cnc(NC(CO)CO)nc2N)cc1I
Structure
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