| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 5 |
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| Ligand | BDBM50257636 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_565946 (CHEMBL960841) |
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| IC50 | >10000±n/a nM |
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| Citation |  Carter, DS; Alam, M; Cai, H; Dillon, MP; Ford, AP; Gever, JR; Jahangir, A; Lin, C; Moore, AG; Wagner, PJ; Zhai, Y Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett19:1628-31 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 5 |
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| Name: | P2X purinoceptor 5 |
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| Synonyms: | ATP receptor | P2RX5 | P2RX5_HUMAN | P2X5 | Purinergic receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47208.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_612725 |
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| Residue: | 422 |
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| Sequence: | MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDT
SLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAE
NEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEP
FLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRW
AGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARY
YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDS
SQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR
ST
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| BDBM50257636 |
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| n/a |
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| Name | BDBM50257636 |
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| Synonyms: | 5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine | CHEMBL526307 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17IN4O2 |
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| Mol. Mass. | 400.2149 |
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| SMILES | COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I |
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| Structure | 
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