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TargetP2X purinoceptor 3
LigandBDBM50413384
Substrate/Competitorn/a
Meas. Tech.ChEMBL_565941 (CHEMBL960836)
IC50<10000±n/a nM
Citation Carter, DSAlam, MCai, HDillon, MPFord, APGever, JRJahangir, ALin, CMoore, AGWagner, PJZhai, Y Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett19:1628-31 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
P2X purinoceptor 3
Name:P2X purinoceptor 3
Synonyms:ATP receptor | P2RX3_RAT | P2X purinoceptor 3 | P2X3 | P2rx3 | Purinergic receptor | ratp2x3 | ratp2x3 + rsa
Type:Enzyme Catalytic Domain
Mol. Mass.:44397.63
Organism:RAT
Description:Purinergic, P2X3 0 RAT::P49654
Residue:397
Sequence:
MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDS
QCGPERFPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEE
VTETTLKGTASTNPVFASDQATVEKQSTDSGAYSIGH
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  Blast E-value cutoff:
BDBM50413384
n/a
NameBDBM50413384
Synonyms:CHEMBL510124
TypeSmall organic molecule
Emp. Form.C16H22N4O2
Mol. Mass.302.3715
SMILESCCc1cc(OC)c(OC)cc1CCc1cnc(N)nc1N
Structure
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