Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCoagulation factor X
LigandBDBM50266743
Substrate/Competitorn/a
Meas. Tech.ChEMBL_563985 (CHEMBL956028)
IC50 0.18±n/a nM
Citation Van Huis, CACasimiro-Garcia, ABigge, CFCody, WLDudley, DAFilipski, KJHeemstra, RJKohrt, JTLeadley, RJNarasimhan, LSMcClanahan, TMochalkin, IPamment, MPeterson, JTSahasrabudhe, VSchaum, RPEdmunds, JJ Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action. Bioorg Med Chem17:2501-11 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50266743
n/a
NameBDBM50266743
Synonyms:(2R,4S)-N1-(4-Chlorophenyl)-4-hydroxy-N2-(5-(2-oxopyridin-1(2H)-yl)pyridin-2-yl)-4-p-tolylpyrrolidine-1,2-dicarboxamide | CHEMBL475280
TypeSmall organic molecule
Emp. Form.C29H26ClN5O4
Mol. Mass.544.001
SMILESCc1ccc(cc1)[C@@]1(O)C[C@@H](N(C1)C(=O)Nc1ccc(Cl)cc1)C(=O)Nc1ccc(cn1)-n1ccccc1=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: