| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ITK/TSK |
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| Ligand | BDBM50257803 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_562396 (CHEMBL1018829) |
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| IC50 | 6±n/a nM |
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| Citation |  Riether, D; Zindell, R; Kowalski, JA; Cook, BN; Bentzien, J; Lombaert, SD; Thomson, D; Kugler, SZ; Skow, D; Martin, LS; Raymond, EL; Khine, HH; O'Shea, K; Woska, JR; Jeanfavre, D; Sellati, R; Ralph, KL; Ahlberg, J; Labissiere, G; Kashem, MA; Pullen, SS; Takahashi, H 5-Aminomethylbenzimidazoles as potent ITK antagonists. Bioorg Med Chem Lett19:1588-91 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ITK/TSK |
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| Name: | Tyrosine-protein kinase ITK/TSK |
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| Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
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| Type: | Protein |
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| Mol. Mass.: | 71839.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08881 |
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| Residue: | 620 |
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| Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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| BDBM50257803 |
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| n/a |
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| Name | BDBM50257803 |
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| Synonyms: | CHEMBL521695 | N-(1-(2-hydroxy-2-methylpropyl)-5-((methyl(pyridin-3-ylmethyl)amino)methyl)-1H-benzo[d]imidazol-2(3H)-ylidene)-5-(1H-pyrazol-4-yl)thiophene-2-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29N7O2S |
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| Mol. Mass. | 515.63 |
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| SMILES | CN(Cc1cccnc1)Cc1ccc2n(CC(C)(C)O)c(NC(=O)c3ccc(s3)-c3cn[nH]c3)nc2c1 |
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| Structure | 
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