Ki Summary

Reaction Details

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Target

Cannabinoid receptor 2

Ligand

BDBM50169953

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_564385 (CHEMBL962380)

14±n/a nM

Citation

Ferreira, AM; Krishnamurthy, M; Moore, BM; Finkelstein, D; Bashford, D Quantitative structure-activity relationship (QSAR) for a series of novel cannabinoid derivatives using descriptors derived from semi-empirical quantum-chemical calculations. Bioorg Med Chem17:2598-606 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cannabinoid receptor 2

Name:

Cannabinoid receptor 2

Synonyms:

CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

39690.94

Organism:

Homo sapiens (Human)

Description:

P34972

Residue:

360

Sequence:

MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC

BDBM50169953

n/a

Name

BDBM50169953

Synonyms:

(6aR,10aR)-3-Adamantan-2-yl-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol | AM-744 | CHEMBL371167

Type

Small organic molecule

Emp. Form.

C26H34O2

Mol. Mass.

378.547

SMILES

CC1=CC[C@@H]2[C@@H](C1)c1c(O)cc(cc1OC2(C)C)C1C2CC3CC(C2)CC1C3 |r,wU:5.5,wD:4.3,t:1,TLB:11:18:20:24.22.23,THB:22:21:18:24.23.25,22:23:20.21.27:18,25:23:20:27.26.18,25:26:20:24.22.23,(23.06,6.7,;23.06,5.15,;21.72,4.37,;21.72,2.82,;23.06,2.06,;24.39,2.82,;24.39,4.37,;25.72,2.06,;27.05,2.82,;27.06,4.36,;28.38,2.04,;28.37,.5,;27.03,-.26,;25.71,.52,;24.38,-.25,;23.05,.52,;21.55,.13,;22.64,-.97,;29.71,-.28,;29.72,-1.77,;28.51,-3.06,;30.02,-2.63,;31.43,-3.2,;32.45,-1.92,;31.05,-2.27,;32.47,-.38,;31.06,.2,;30.01,-1.04,)|

Structure