Reaction Details |
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Target | Tyrosine-protein kinase SYK |
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Ligand | BDBM4363 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_499518 (CHEMBL1022010) |
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IC50 | 38000±n/a nM |
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Citation | Xie, HZ; Li, LL; Ren, JX; Zou, J; Yang, L; Wei, YQ; Yang, SY Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors. Bioorg Med Chem Lett19:1944-9 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase SYK |
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Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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BDBM4363 |
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n/a |
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Name | BDBM4363 |
Synonyms: | (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide | AG 213 | CHEMBL77030 | RG-50864 | T7540 (Tyrphostin 47) | Tyrphostin A47 | alpha-Cyano-(3,4-dihydroxy)thiocinnamide | benzylidenemalononitrile (BMN) deriv. 47 |
Type | Small organic molecule |
Emp. Form. | C10H8N2O2S |
Mol. Mass. | 220.248 |
SMILES | NC(=S)C(=C\c1ccc(O)c(O)c1)\C#N |
Structure |
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