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TargetHistone deacetylase 1
LigandBDBM50278466
Substrate/Competitorn/a
Meas. Tech.ChEMBL_564614 (CHEMBL964054)
IC50 3.5±n/a nM
Citation Heidebrecht, RWChenard, MClose, JDahlberg, WKFleming, JGrimm, JBHamill, JEHarsch, AHaines, BBHughes, BKral, AMMiddleton, REMushti, COzerova, NSzewczak, AAWang, HWilson, KWitter, DJSecrist, JPMiller, TA Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2). Bioorg Med Chem Lett19:2053-8 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 1
Name:Histone deacetylase 1
Synonyms:Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:Enzyme
Mol. Mass.:55090.27
Organism:Homo sapiens (Human)
Description:Q13547
Residue:482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50278466
n/a
NameBDBM50278466
Synonyms:CHEMBL470421 | pyridin-3-ylmethyl 4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl(methyl)phosphinate
TypeSmall organic molecule
Emp. Form.C25H24N3O3PS
Mol. Mass.477.515
SMILESCP(=O)(Cc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1)OCc1cccnc1
Structure
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