Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50278469 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_564614 (CHEMBL964054) |
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IC50 | 54±n/a nM |
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Citation | Heidebrecht, RW; Chenard, M; Close, J; Dahlberg, WK; Fleming, J; Grimm, JB; Hamill, JE; Harsch, A; Haines, BB; Hughes, B; Kral, AM; Middleton, RE; Mushti, C; Ozerova, N; Szewczak, AA; Wang, H; Wilson, K; Witter, DJ; Secrist, JP; Miller, TA Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2). Bioorg Med Chem Lett19:2053-8 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50278469 |
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n/a |
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Name | BDBM50278469 |
Synonyms: | CHEMBL469378 | methyl 4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl(methyl)phosphinate |
Type | Small organic molecule |
Emp. Form. | C20H21N2O3PS |
Mol. Mass. | 400.431 |
SMILES | COP(C)(=O)Cc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1 |
Structure |
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