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TargetPotassium voltage-gated channel subfamily A member 3
LigandBDBM50279107
Substrate/Competitorn/a
Meas. Tech.ChEMBL_545452 (CHEMBL1032475)
IC50 5000±n/a nM
Citation Pegoraro, S; Lang, M; Dreker, T; Kraus, J; Hamm, S; Meere, C; Feurle, J; Tasler, S; Prütting, S; Kuras, Z; Visan, V; Grissmer, S Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett19:2299-304 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium voltage-gated channel subfamily A member 3
Name:Potassium voltage-gated channel subfamily A member 3
Synonyms:HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:PROTEIN
Mol. Mass.:63835.47
Organism:Homo sapiens (Human)
Description:ChEMBL_1513935
Residue:575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDH
LLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLK
TLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIF
SEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVS
VLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVET
LCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSL
AILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE
ADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIV
SNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHS
AFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50279107
n/a
NameBDBM50279107
Synonyms:1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | CHEMBL498270
TypeSmall organic molecule
Emp. Form.C22H17ClN2
Mol. Mass.344.837
SMILESClc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1
Structure
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