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TargetIntermediate conductance calcium-activated potassium channel protein 4
LigandBDBM50279065
Substrate/Competitorn/a
Meas. Tech.ChEMBL_545455
IC50 1400±n/a nM
Citation Pegoraro SLang MDreker TKraus JHamm SMeere CFeurle JTasler SPrütting SKuras ZVisan VGrissmer S Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett 19:2299-304 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Intermediate conductance calcium-activated potassium channel protein 4
Name:Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:IK1 | IKCa1 | KCa4 | Putative Gardos channel | SK4
Type:PROTEIN
Mol. Mass.:47723.22
Organism:Homo sapiens (Human)
Description:ChEMBL_1361891
Residue:427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
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  Blast E-value cutoff:
BDBM50279065
n/a
NameBDBM50279065
Synonyms:5-(4-chlorophenylsulfonyl)-5H-dibenzo[b,d]azepin-7(6H)-one | CHEMBL522750
TypeSmall organic molecule
Emp. Form.C20H14ClNO3S
Mol. Mass.383.848
SMILESClc1ccc(cc1)S(=O)(=O)N1CC(=O)c2ccccc2-c2ccccc12
Structure
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