| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 3 |
|---|
| Ligand | BDBM50278221 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_565675 (CHEMBL960033) |
|---|
| IC50 | 659±n/a nM |
|---|
| Citation |  Giannini, G; Marzi, M; Pezzi, R; Brunetti, T; Battistuzzi, G; Marzo, MD; Cabri, W; Vesci, L; Pisano, C N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett19:2346-9 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 3 |
|---|
| Name: | Histone deacetylase 3 |
|---|
| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48829.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O15379 |
|---|
| Residue: | 428 |
|---|
| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
|
|
|
|---|
| BDBM50278221 |
|---|
| n/a |
|---|
| Name | BDBM50278221 |
|---|
| Synonyms: | CHEMBL471043 | methyl 4-((4-(3-(hydroxyamino)-3-oxoprop-1-enyl)benzylideneaminooxy)methyl)benzoate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H18N2O5 |
|---|
| Mol. Mass. | 354.3566 |
|---|
| SMILES | COC(=O)c1ccc(CO\N=C\c2ccc(\C=C\C(=O)NO)cc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
