| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 3 |
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| Ligand | BDBM50278344 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_565675 (CHEMBL960033) |
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| IC50 | 3140±n/a nM |
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| Citation |  Giannini, G; Marzi, M; Pezzi, R; Brunetti, T; Battistuzzi, G; Marzo, MD; Cabri, W; Vesci, L; Pisano, C N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett19:2346-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 3 |
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| Name: | Histone deacetylase 3 |
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| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48829.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15379 |
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| Residue: | 428 |
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| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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| BDBM50278344 |
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| n/a |
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| Name | BDBM50278344 |
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| Synonyms: | CHEMBL470843 | N-hydroxy-3-(4-(5-(morpholinomethyl)isoxazol-3-yl)phenyl)acrylamide hydrochloride |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19N3O4 |
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| Mol. Mass. | 329.3505 |
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| SMILES | ONC(=O)\C=C\c1ccc(cc1)-c1cc(CN2CCOCC2)on1 |
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| Structure | 
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