| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50278219 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_565680 (CHEMBL960038) |
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| IC50 | 1290±n/a nM |
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| Citation |  Giannini, G; Marzi, M; Pezzi, R; Brunetti, T; Battistuzzi, G; Marzo, MD; Cabri, W; Vesci, L; Pisano, C N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett19:2346-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50278219 |
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| n/a |
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| Name | BDBM50278219 |
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| Synonyms: | CHEMBL471041 | N-hydroxy-3-(4-((perfluorobenzyloxyimino)methyl)phenyl)acrylamide | ST-2986 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11F5N2O3 |
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| Mol. Mass. | 386.2729 |
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| SMILES | ONC(=O)\C=C\c1ccc(\C=N\OCc2c(F)c(F)c(F)c(F)c2F)cc1 |
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| Structure | 
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