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TargetCoagulation factor X
LigandBDBM50249118
Substrate/Competitorn/a
Meas. Tech.ChEMBL_499722
IC50 0.5±n/a nM
Citation Zhang PHuang WWang LBao LJia ZJBauer SMGoldman EAProbst GDSong YSu TFan JWu YLi WWoolfrey JSinha UWong PWEdwards STArfsten AEClizbe LAKanter JPandey APark GHutchaleelaha ALambing JLHollenbach SJScarborough RMZhu BY Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett 19:2179-85 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50249118
n/a
NameBDBM50249118
Synonyms:5-chloro-N-(5-chloropyridin-2-yl)-3-(dimethylamino)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)benzamide | CHEMBL513981
TypeSmall organic molecule
Emp. Form.C24H24Cl2N6O2
Mol. Mass.499.392
SMILESCN(C)C(=N)c1ccc(cc1)C(=O)Nc1c(cc(Cl)cc1C(=O)Nc1ccc(Cl)cn1)N(C)C
Structure
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