| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50193842 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_499722 (CHEMBL968695) |
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| IC50 | 0.9±n/a nM |
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| Citation |  Zhang, P; Huang, W; Wang, L; Bao, L; Jia, ZJ; Bauer, SM; Goldman, EA; Probst, GD; Song, Y; Su, T; Fan, J; Wu, Y; Li, W; Woolfrey, J; Sinha, U; Wong, PW; Edwards, ST; Arfsten, AE; Clizbe, LA; Kanter, J; Pandey, A; Park, G; Hutchaleelaha, A; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett19:2179-85 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50193842 |
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| n/a |
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| Name | BDBM50193842 |
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| Synonyms: | 1-(2-(2-(5-chloropyridin-2-ylcarbamoyl)-4-methoxyphenylcarbamoyl)-5-(N,N-dimethylcarbamimidoyl)phenyl)piperidine-4-carboxylic acid | 1-[2-[2-(5-chloro-pyridin-2-ylcarbamoyl)-4-methoxy-phenylcarbamoyl]-5-(N,N-dimethyl-carbamimidoyl)-phenyl]-piperidine-4-carboxylic acid | CHEMBL218315 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31ClN6O5 |
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| Mol. Mass. | 579.047 |
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| SMILES | COc1ccc(NC(=O)c2ccc(cc2N2CCC(CC2)C(O)=O)C(=N)N(C)C)c(c1)C(=O)Nc1ccc(Cl)cn1 |
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| Structure | 
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