| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50257025 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_562705 (CHEMBL1012740) |
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| Ki | 0.38±n/a nM |
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| Citation |  Colotta, V; Lenzi, O; Catarzi, D; Varano, F; Filacchioni, G; Martini, C; Trincavelli, L; Ciampi, O; Pugliese, AM; Traini, C; Pedata, F; Morizzo, E; Moro, S Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies. J Med Chem52:2407-19 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | AA1R_BOVIN | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 36602.99 |
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| Organism: | BOVINE |
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| Description: | ADENOSINE 0 BOVINE::P28190 |
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| Residue: | 326 |
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| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
PRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPVDEDAPAERPDD
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| BDBM50257025 |
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| n/a |
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| Name | BDBM50257025 |
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| Synonyms: | 4-(cyclohexylamino)-2-phenylpyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1(2H)-one | CHEMBL473648 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20N6O |
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| Mol. Mass. | 360.4124 |
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| SMILES | O=c1n(nc2c(NC3CCCCC3)nc3ncccc3n12)-c1ccccc1 |
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| Structure | 
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