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TargetThromboxane A2 receptor
LigandBDBM50277938
Substrate/Competitorn/a
Meas. Tech.ChEMBL_501283 (CHEMBL971469)
Ki 172±n/a nM
Citation Leblanc, YRoy, PDufresne, CLachance, NWang, ZO'Neill, GGreig, GDenis, DMathieu, MCSlipetz, DSawyer, NTsou, N Discovery of potent and selective DP1 receptor antagonists in the azaindole series. Bioorg Med Chem Lett19:2125-8 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thromboxane A2 receptor
Name:Thromboxane A2 receptor
Synonyms:Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:Enyzme
Mol. Mass.:37445.28
Organism:Homo sapiens (Human)
Description:P21731
Residue:343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50277938
n/a
NameBDBM50277938
Synonyms:(+/-)-2-(4-(methylsulfonyl)-5-(p-tolylthio)-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-6-yl)acetic acid | CHEMBL485535
TypeSmall organic molecule
Emp. Form.C21H22N2O4S2
Mol. Mass.430.54
SMILESCc1ccc(Sc2c3C(CC(O)=O)CCCn3c3nccc(c23)S(C)(=O)=O)cc1
Structure
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