Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHydroxycarboxylic acid receptor 2
LigandBDBM50277579
Substrate/Competitorn/a
Meas. Tech.ChEMBL_501337 (CHEMBL971523)
IC50 5±n/a nM
Citation Shen, HCDing, FXDeng, QWilsie, LCKrsmanovic, MLTaggart, AKCarballo-Jane, ERen, NCai, TQWu, TJWu, KKCheng, KChen, QWolff, MSTong, XHolt, TGWaters, MGHammond, MLTata, JRColletti, SL Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats. J Med Chem52:2587-602 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 2
Name:Hydroxycarboxylic acid receptor 2
Synonyms:G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41868.22
Organism:Homo sapiens (Human)
Description:Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50277579
n/a
NameBDBM50277579
Synonyms:2-(3-(7-hydroxy-2H-benzo[g]indazol-3-yl)propanamido)benzoic acid | CHEMBL483352
TypeSmall organic molecule
Emp. Form.C21H17N3O4
Mol. Mass.375.3774
SMILESOC(=O)c1ccccc1NC(=O)CCc1[nH]nc2c1ccc1cc(O)ccc21
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: