| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50267297 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_563306 (CHEMBL981942) |
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| Ki | >4000±n/a nM |
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| Citation |  Degoey, DA; Grampovnik, DJ; Flentge, CA; Flosi, WJ; Chen, HJ; Yeung, CM; Randolph, JT; Klein, LL; Dekhtyar, T; Colletti, L; Marsh, KC; Stoll, V; Mamo, M; Morfitt, DC; Nguyen, B; Schmidt, JM; Swanson, SJ; Mo, H; Kati, WM; Molla, A; Kempf, DJ 2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects. J Med Chem52:2571-86 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50267297 |
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| n/a |
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| Name | BDBM50267297 |
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| Synonyms: | CHEMBL507731 | Methyl (S)-1-((2S,4S,5S)-5-((S)-2-(3-Benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanamido)-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C47H60N6O6 |
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| Mol. Mass. | 805.0159 |
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| SMILES | COC(=O)N[C@H](C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCN(Cc2ccccc2)C1=O)C(C)(C)C)Cc1ccc(cc1)-c1ccccn1)C(C)(C)C |r| |
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| Structure | 
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