| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 2 |
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| Ligand | BDBM50259271 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_500189 |
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| IC50 | 8400±n/a nM |
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| Citation |  Debenham JS; Madsen-Duggan CB; Wang J; Tong X; Lao J; Fong TM; Schaeffer MT; Xiao JC; Huang CC; Shen CP; Sloan Stribling D; Shearman LP; Strack AM; Euan Macintyre D; Hale JJ; Walsh TF Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation. Bioorg Med Chem Lett 19:2591-4 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 2 |
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| Name: | Cannabinoid receptor 2 |
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| Synonyms: | CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 39690.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34972 |
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| Residue: | 360 |
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| Sequence: | MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
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| BDBM50259271 |
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| n/a |
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| Name | BDBM50259271 |
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| Synonyms: | 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)-4-methoxypyrido[2,3-d]pyrimidine | CHEMBL513121 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21Cl2N3O |
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| Mol. Mass. | 438.349 |
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| SMILES | COc1nc(nc2nc(-c3ccccc3Cl)c(cc12)-c1ccc(Cl)cc1)C(C)(C)C |
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| Structure | 
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