Reaction Details |
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Target | Nociceptin receptor |
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Ligand | BDBM50259099 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_500499 (CHEMBL1009676) |
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EC50 | 269±n/a nM |
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Citation | Yang, SW; Ho, G; Tulshian, D; Greenlee, WJ; Tan, Z; Zhang, H; Smith-Torhan, A; Fawzi, A; Anthes, J; Lu, S; Varty, G; Fernandez, X; McLeod, RL; Hey, J Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety. Bioorg Med Chem Lett19:2482-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nociceptin receptor |
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Name: | Nociceptin receptor |
Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40702.87 |
Organism: | Homo sapiens (Human) |
Description: | P41146 |
Residue: | 370 |
Sequence: | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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BDBM50259099 |
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n/a |
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Name | BDBM50259099 |
Synonyms: | CHEMBL3084527 | endo-N-((8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octan-3-yl)methyl)acetamide |
Type | Small organic molecule |
Emp. Form. | C29H30Cl2N2O |
Mol. Mass. | 493.467 |
SMILES | [H][C@]12CC[C@]([H])(C[C@@](CNC(C)=O)(C1)c1ccccc1)N2C(c1ccccc1Cl)c1ccccc1Cl |r,TLB:8:7:20:3.2| |
Structure |
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