| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
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| Ligand | BDBM50259108 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_500742 (CHEMBL970521) |
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| IC50 | >10000±n/a nM |
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| Citation |  Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents. Bioorg Med Chem Lett19:2537-41 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
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| Name: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
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| Synonyms: | PDE8B | PDE8B_HUMAN | Phosphodiesterase 8 | Phosphodiesterase 8B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 98984.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_876321 |
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| Residue: | 885 |
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| Sequence: | MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER
MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK
ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA
DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF
ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
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| BDBM50259108 |
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| n/a |
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| Name | BDBM50259108 |
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| Synonyms: | (-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)cyclohexyl]methyl}-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one | CHEMBL466481 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25N7O |
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| Mol. Mass. | 367.4481 |
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| SMILES | CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O |r| |
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| Structure | 
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