Reaction Details |
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Target | Substance-K receptor |
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Ligand | BDBM50277511 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_501453 (CHEMBL994713) |
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Ki | 2.4±n/a nM |
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Citation | Jiang, J; Bunda, JL; Doss, GA; Chicchi, GG; Kurtz, MM; Tsao, KL; Tong, X; Zheng, S; Upthagrove, A; Samuel, K; Tschirret-Guth, R; Kumar, S; Wheeldon, A; Carlson, EJ; Hargreaves, R; Burns, D; Hamill, T; Ryan, C; Krause, SM; Eng, W; DeVita, RJ; Mills, SG Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists. J Med Chem52:3039-46 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-K receptor |
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Name: | Substance-K receptor |
Synonyms: | NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3 |
Type: | Protein |
Mol. Mass.: | 44455.78 |
Organism: | Homo sapiens (Human) |
Description: | P21452 |
Residue: | 398 |
Sequence: | MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
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BDBM50277511 |
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n/a |
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Name | BDBM50277511 |
Synonyms: | 3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-4-(4-fluorophenyl)octahydro-1H-isoindol-2-yl]cyclopent-2-en-1-one | CHEMBL447955 |
Type | Small organic molecule |
Emp. Form. | C29H28F7NO2 |
Mol. Mass. | 555.5269 |
SMILES | C[C@@H](O[C@H]1CC[C@@H]2CN(C[C@H]2[C@@H]1c1ccc(F)cc1)C1=CC(=O)CC1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,t:22| |
Structure |
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