| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform gamma-1 |
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| Ligand | BDBM50259563 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_499154 (CHEMBL1011428) |
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| IC50 | 160±n/a nM |
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| Citation |  Lovering, F; Kirincich, S; Wang, W; Combs, K; Resnick, L; Sabalski, JE; Butera, J; Liu, J; Parris, K; Telliez, JB Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem17:3342-51 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform gamma-1 |
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| Name: | Casein kinase I isoform gamma-1 |
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| Synonyms: | CKI-gamma 1 | CSNK1G1 | Casein kinase I | Casein kinase I gamma 1 isoform | Casein kinase I isoform gamma-1 | KC1G1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48530.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774608 |
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| Residue: | 422 |
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| Sequence: | MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL
GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL
LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE
HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM
FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE
KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP
SQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQR
HK
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| BDBM50259563 |
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| n/a |
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| Name | BDBM50259563 |
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| Synonyms: | 2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl]amino}-2-(3-hydroxyphenyl)acetamide | CHEMBL511410 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14N4O4 |
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| Mol. Mass. | 338.3175 |
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| SMILES | NC(=O)C(Nc1c(Nc2ccncc2)c(=O)c1=O)c1cccc(O)c1 |
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| Structure | 
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