| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-2 adrenergic receptor |
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| Ligand | BDBM50236182 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_497790 (CHEMBL1007086) |
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| EC50 | >1000±n/a nM |
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| Citation |  Hattori, K; Toda, S; Imanishi, M; Itou, S; Nakajima, Y; Washizuka, K; Araki, T; Hamashima, H; Tomishima, Y; Sakurai, M; Matsui, S; Imamura, E; Ueshima, K; Yamamoto, T; Yamamoto, N; Ishikawa, H; Nakano, K; Unami, N; Hamada, K; Matsumura, Y; Takamura, F Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5. J Med Chem52:3063-72 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-2 adrenergic receptor |
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| Name: | Beta-2 adrenergic receptor |
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| Synonyms: | ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor |
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| Type: | n/a |
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| Mol. Mass.: | 46461.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07550 |
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| Residue: | 413 |
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| Sequence: | MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
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| BDBM50236182 |
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| n/a |
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| Name | BDBM50236182 |
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| Synonyms: | (R)-4'-(2-(2-(3-chlorophenyl)-2-hydroxyethylamino)ethyl)-3-methoxybiphenyl-4-carboxylic acid | 4'-{2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-ethyl}-3-methoxy-biphenyl-4-carboxylic acid | 4-(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-ethyl)-3-methoxy-4-biphenyl-4-carboxylic acid | CHEMBL272383 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24ClNO4 |
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| Mol. Mass. | 425.905 |
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| SMILES | COc1cc(ccc1C(O)=O)-c1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1 |r| |
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| Structure | 
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