| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM50258743 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_500316 (CHEMBL973408) |
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| Ki | 550±n/a nM |
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| Citation |  Cox, CD; McGaughey, GB; Bogusky, MJ; Whitman, DB; Ball, RG; Winrow, CJ; Renger, JJ; Coleman, PJ Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding. Bioorg Med Chem Lett19:2997-3001 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
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| Type: | Protein |
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| Mol. Mass.: | 50710.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43614 |
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| Residue: | 444 |
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| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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| BDBM50258743 |
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| n/a |
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| Name | BDBM50258743 |
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| Synonyms: | CHEMBL511604 | cyclohexyl(4-(quinazolin-2-yl)-1,4-diazepan-1-yl)methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N4O |
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| Mol. Mass. | 338.4466 |
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| SMILES | O=C(C1CCCCC1)N1CCCN(CC1)c1ncc2ccccc2n1 |
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| Structure | 
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