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TargetBeta-carbonic anhydrase 1
LigandBDBM50258635
Substrate/Competitorn/a
Meas. Tech.ChEMBL_519733 (CHEMBL938996)
Ki 7.6±n/a nM
Citation Güzel, OMaresca, AScozzafava, ASalman, ABalaban, ATSupuran, CT Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273. J Med Chem52:4063-7 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-carbonic anhydrase 1
Name:Beta-carbonic anhydrase 1
Synonyms:β-Carbonic anhydrase 1 (CA 1) | Carbonic Anhydrase (mtCA 1) | MTCA1_MYCTU | Uncharacterized protein Rv1284/MT1322 | canA | mtcA1
Type:Enzyme
Mol. Mass.:18186.06
Organism:Mycobacterium tuberculosis
Description:The recombinant GST-mtCA1 construct was cloned, expressed, and further purified from E. coli. The purified protein was used in inhibition assays.
Residue:163
Sequence:
MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAG
CVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESY
PDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP
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BDBM50258635
n/a
NameBDBM50258635
Synonyms:1-(3-(4-fluorophenyl)-5-sulfamoyl-1H-indole-2-carboxamido)-2,4,6-trimethylpyridinium perchlorate | 1-({[5-(Aminosulfonyl)-3-(4-methylphenyl)-1H-indol-2-yl]carbonyl}amino)-2,4,6 trimethylpyridinium perchlorate | CHEMBL468294
TypeSmall organic molecule
Emp. Form.C23H22FN4O3S
Mol. Mass.453.509
SMILESCc1cc(C)[n+](NC(=O)c2[nH]c3ccc(cc3c2-c2ccc(F)cc2)S(N)(=O)=O)c(C)c1
Structure
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