| Reaction Details |
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 | Report a problem with these data |
| Target | Dynamin-1 |
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| Ligand | BDBM50268961 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_523163 (CHEMBL997155) |
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| IC50 | 14300±n/a nM |
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| Citation |  Hill, TA; Gordon, CP; McGeachie, AB; Venn-Brown, B; Odell, LR; Chau, N; Quan, A; Mariana, A; Sakoff, JA; Chircop, M; Robinson, PJ; McCluskey, A Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem52:3762-73 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dynamin-1 |
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| Name: | Dynamin-1 |
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| Synonyms: | DNM | DNM1 | DYN1_HUMAN | Dynamin-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 97411.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1458576 |
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| Residue: | 864 |
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| Sequence: | MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPI
NLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSD
LANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQK
DIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKL
QSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGA
RINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKI
REPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLID
IELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKE
YWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY
RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVE
TIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAE
QAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT
PQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAP
PGVPSRSGQASPSRPESPRPPFDL
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| BDBM50268961 |
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| n/a |
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| Name | BDBM50268961 |
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| Synonyms: | 2-Cyano-N-hexyl-3-[1-(3-dimethylaminopropyl)-2-methyl-1Hindol-3-yl]-acrylamide | CHEMBL496824 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H34N4O |
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| Mol. Mass. | 394.553 |
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| SMILES | CCCCCCNC(=O)C(=C\c1c(C)n(CCCN(C)C)c2ccccc12)\C#N |
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| Structure | 
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