| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Ligand | BDBM50000766 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_519947 (CHEMBL954626) |
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| Ki | 15±n/a nM |
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| Citation |  Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. J Med Chem52:3723-34 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Name: | Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Synonyms: | GABA A Alpha2Beta2Gamma2 | GABA A alpha2 | GABA A receptor alpha-2/beta-2/gamma-2 | GABA receptor alpha-2 subunit | GABA(A) receptor subunit alpha-2 | GBRA2_RAT | Gabra-2 | Gabra2 | Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 51195.57 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P23576 |
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| Residue: | 451 |
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| Sequence: | MRTKLSTCNVWFPLLVLLVWNPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG
LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNSMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC
PLKFGSYAYTTSEVTYIWTYNPSDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM
TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKGSV
MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM
SRIVFPVLFGTFNLVYWATYLNREPVLGVSP
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| BDBM50000766 |
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| n/a |
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| Name | BDBM50000766 |
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| Synonyms: | CHEMBL12 | DIAZEPAM | US9271961, Diazepam |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13ClN2O |
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| Mol. Mass. | 284.74 |
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| SMILES | CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 |c:10| |
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| Structure | 
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