| Reaction Details |
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 | Report a problem with these data |
| Target | Smoothened homolog |
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| Ligand | BDBM50269112 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_522936 (CHEMBL995458) |
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| IC50 | 1.3±n/a nM |
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| Citation |  Miller-Moslin, K; Peukert, S; Jain, RK; McEwan, MA; Karki, R; Llamas, L; Yusuff, N; He, F; Li, Y; Sun, Y; Dai, M; Perez, L; Michael, W; Sheng, T; Lei, H; Zhang, R; Williams, J; Bourret, A; Ramamurthy, A; Yuan, J; Guo, R; Matsumoto, M; Vattay, A; Maniara, W; Amaral, A; Dorsch, M; Kelleher, JF 1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity. J Med Chem52:3954-68 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Smoothened homolog |
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| Name: | Smoothened homolog |
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| Synonyms: | SMO_MOUSE | Smo | Smoh |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87472.73 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1510377 |
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| Residue: | 793 |
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| Sequence: | MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSP
PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAP
RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE
GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA
FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR
ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK
TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG
YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN
QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV
WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH
DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWL
VEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLV
AANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN
LMEAEILDADSDF
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| BDBM50269112 |
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| n/a |
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| Name | BDBM50269112 |
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| Synonyms: | 1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}1-methylethylamine | CHEMBL497266 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30N6 |
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| Mol. Mass. | 438.5673 |
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| SMILES | CC(C)(N)c1ccc(nc1)N1CCN(CC1)c1nnc(Cc2ccccc2)c2ccccc12 |
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| Structure | 
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