| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50233341 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_523905 (CHEMBL1001498) |
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| IC50 | 1±n/a nM |
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| Citation |  Cherney, RJ; Mo, R; Meyer, DT; Voss, ME; Lo, YC; Yang, G; Miller, PB; Scherle, PA; Tebben, AJ; Carter, PH; Decicco, CP Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists. Bioorg Med Chem Lett19:3418-22 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50233341 |
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| n/a |
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| Name | BDBM50233341 |
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| Synonyms: | 2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylthio)benzamido)cyclohexylamino)-2-oxoethyl)-5-(trifluoromethyl)benzamide | CHEMBL273083 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H34F3N5O4S |
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| Mol. Mass. | 593.661 |
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| SMILES | CSc1ccc(cc1)C(=O)N[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1cc(ccc1NC(=O)NC(C)C)C(F)(F)F |r| |
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| Structure | 
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