| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
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| Ligand | BDBM50057448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_204583 |
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| Ki | 7±n/a nM |
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| Citation |  Holt, DA; Levy, MA; Yen, HK; Oh, HJ; Metcalf, BW; Wier, PJ Inhibition of steroid 5α-reductase by 3-nitrosteroids: synthesis, mechanism of inhibition, and in vivo activity. Bioorg Med Chem Lett1:27-32 (1991) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
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| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
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| Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase |
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| Type: | Enzyme |
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| Mol. Mass.: | 28406.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31213 |
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| Residue: | 254 |
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| Sequence: | MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFIF
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| BDBM50057448 |
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| n/a |
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| Name | BDBM50057448 |
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| Synonyms: | (10R,13S,17S)-17-Diisopropylcarbamoyl-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | 17-Diisopropylcarbamoyl-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | CHEMBL278283 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H41NO3 |
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| Mol. Mass. | 427.6193 |
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| SMILES | CC(C)N(C(C)C)C(=O)[C@H]1CCC2C3CC=C4C=C(CC[C@]4(C)C3CC[C@]12C)C(O)=O |c:17,t:15| |
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| Structure | 
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