| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neutrophil elastase |
|---|
| Ligand | BDBM50280338 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_96619 (CHEMBL708177) |
|---|
| Ki | 17500±n/a nM |
|---|
| Citation |  Groutas, WC; Brubaker, MJ; Venkataraman, R; Epp, JB; Houser-Archield, N; Chong, LS; McClenahan, JJ Potential mechanism-based inhibitors of proteolytic enzymes Bioorg Med Chem Lett2:175-180 (1992) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neutrophil elastase |
|---|
| Name: | Neutrophil elastase |
|---|
| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28532.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08246 |
|---|
| Residue: | 267 |
|---|
| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
|
|
|
|---|
| BDBM50280338 |
|---|
| n/a |
|---|
| Name | BDBM50280338 |
|---|
| Synonyms: | 2-((S)-3-Amino-5-methyl-2-oxo-hexyl)-isoindole-1,3-dione; hydrochloride | CHEMBL542119 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H18N2O3 |
|---|
| Mol. Mass. | 274.315 |
|---|
| SMILES | CC(C)C[C@H](N)C(=O)CN1C(=O)c2ccccc2C1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
