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TargetAcyl-CoA:cholesterol acyltransferase
LigandBDBM50051901
Substrate/Competitorn/a
Meas. Tech.ChEMBL_48787 (CHEMBL662440)
IC50 40±n/a nM
Citation Ashton, MJBridge, AWBush, RCDron, DIHarris, NVJones, GDLythgoe, DJRiddell, DSmith, C RP 70676: A potent systematically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT) Bioorg Med Chem Lett2:375-380 (1992)    Article
More Info.:Get all data from this article,  Assay Method
 
Acyl-CoA:cholesterol acyltransferase
Name:Acyl-CoA:cholesterol acyltransferase
Synonyms:ACAT
Type:n/a
Mol. Mass.:35405.31
Organism:Oryctolagus cuniculus
Description:n/a
Residue:305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
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  Blast E-value cutoff:
BDBM50051901
n/a
NameBDBM50051901
Synonyms:1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-pentyl]-3,5-dimethyl-1H-pyrazole | CHEMBL33780
TypeSmall organic molecule
Emp. Form.C25H28N4S
Mol. Mass.416.582
SMILESCc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1
Structure
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