| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
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| Ligand | BDBM50280416 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_48914 |
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| IC50 | 14±n/a nM |
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| Citation |  Ashton, MJ; Bridge, AW; Bush, RC; Dron, DI; Harris, NV; Jones, GD; Lythgoe, DJ; Riddell, D; Smith, C RP 70676: A potent systematically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT) Bioorg Med Chem Lett2:375-380 (1992) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 1 |
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| Name: | Sterol O-acyltransferase 1 |
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| Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64165.56 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_28796 |
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| Residue: | 545 |
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| Sequence: | MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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| BDBM50280416 |
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| n/a |
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| Name | BDBM50280416 |
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| Synonyms: | 2-[3-(1-Methyl-1H-imidazol-2-ylsulfanyl)-propylsulfanyl]-4,5-diphenyl-1H-imidazole | CHEMBL340487 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N4S2 |
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| Mol. Mass. | 406.567 |
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| SMILES | Cn1ccnc1SCCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1 |
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| Structure | 
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