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TargetMuscarinic acetylcholine receptor M1
LigandBDBM50003351
Substrate/Competitorn/a
Meas. Tech.ChEBML_139952
IC50 5±n/a nM
Citation Sauerberg POlesen PHSuzdak PDSheardown MJMitch CHSawyer BDShannon HE Synthesis and structure-activity relationships of heterocyclic analogues of the functional M1 selective muscarinic agonist hexyloxy-TZTP Bioorg Med Chem Lett 2:809-814 (1992)    Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M1
Name:Muscarinic receptor M1 and M2
Synonyms:Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:Enzyme Catalytic Domain
Mol. Mass.:51390.46
Organism:RAT
Description:Cholinergic, muscarinic M1 CHRM1 RAT::P08482
Residue:460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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  Blast E-value cutoff:
BDBM50003351
n/a
NameBDBM50003351
Synonyms:3-(4-butoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5,6-tetrahydropyridine | 5-(4-Butoxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine | 5-(4-Butoxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine; oxalic acid | CHEMBL101054
TypeSmall organic molecule
Emp. Form.C12H19N3OS
Mol. Mass.253.364
SMILESCCCCOc1nsnc1C1=CCCN(C)C1 |t:11|
Structure
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