| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor |
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| Ligand | BDBM50280824 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_33416 (CHEMBL648812) |
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| IC50 | >100±n/a nM |
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| Citation |  Mignani, S; Damour, D; Doble, A; Labaudinière, R; Malleron, JL; Piot, O; Gueremy, C New indole derivatives as potent and selective serotonin uptake inhibitors Bioorg Med Chem Lett3:1913-1918 (1993) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor |
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| Name: | Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor |
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| Synonyms: | Alpha-1 adrenergic receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 33416 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Alpha-1D adrenergic receptor |
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| Synonyms: | ADA1D_MOUSE | Adra1a | Adra1d | Alpha-1 adrenergic receptor | Gpcr8 | adrenergic Alpha2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59890.14 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P97714 |
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| Residue: | 562 |
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| Sequence: | MTFRDILSVTFEGPRASSSTGGSGAGGGAGTVGPEGPAVGGVPGATGGSAVVGTGSGEDN
QSSTAEAGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRH
LQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWPFGRTFCDVWAAVDVLCCTASILS
LCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFC
GITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRI
HCRGAATSAKGNPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFF
VLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR
RLWPSLRPPLASLDRRPALRLCPQPAHRTPRGSPSPHCTPRPGLRRHAGGAGFGLRPSKA
SLRLREWRLLGPLQRPTTQLRAKVSSLSHKFRSGGARRAETACALRSEVEAVSLNVPQDG
AEAVICQAYEPGDLSNLRETDI
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| Component 2 |
| Name: | Alpha-1B adrenergic receptor |
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| Synonyms: | ADA1B_MOUSE | Adra1b | Alpha-1 adrenergic receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 56439.49 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P97717 |
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| Residue: | 514 |
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| Sequence: | MNPDLDTGHNTSAPAHWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGCLGAFILFAIV
GNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTDLPFSATLEVLGYWVLGRIFCDIW
AAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPL
LGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGV
MKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVG
MFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMR
ILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPS
ASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPG
TEGDASNGGCDTTTDLANGQPGFKSNMPLAPGHF
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| Component 3 |
| Name: | Alpha-1A adrenergic receptor |
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| Synonyms: | ADA1A_MOUSE | Adra1a | Adra1c | Alpha-1 adrenergic receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 51769.32 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P97718 |
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| Residue: | 466 |
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| Sequence: | MVLLSENASEGSNCTHPPAQVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINE
EPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
VPAEGSGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPN
FKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTL
HPPSQAVEGQHRGMVRIPVGSGETFYKISKTDGVREWKFFSSMPQGSARITMPKDQSACT
TARVRSKSFLQVCCCVGSSTPRPEENHQVPTIKIHTISLGENGEEV
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| BDBM50280824 |
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| n/a |
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| Name | BDBM50280824 |
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| Synonyms: | 1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1-yl]-ethyl}-1,3-dihydro-indol-2-one | CHEMBL300786 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26FN3O |
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| Mol. Mass. | 391.4811 |
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| SMILES | Fc1ccc2[nH]cc(CC3CCN(CCN4C(=O)Cc5ccccc45)CC3)c2c1 |
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| Structure | 
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