| Reaction Details |
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 | Report a problem with these data |
| Target | Trypanothione reductase |
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| Ligand | BDBM50280881 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_211972 |
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| Ki | 92000±n/a nM |
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| Citation |  Tromelin, A; Moutiez, M; Meziane-Cherif, D; Aumercier, M; Tartar, A; Sergheraert, C Synthesis of non reducible inhibitors for trypanothione reductase from Trypanosoma cruzi. Bioorg Med Chem Lett3:1971-1976 (1993) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Trypanothione reductase |
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| Name: | Trypanothione reductase |
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| Synonyms: | N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYCR |
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| Type: | Homodimer; oxidoreductase |
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| Mol. Mass.: | 53868.26 |
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| Organism: | Trypanosoma cruzi |
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| Description: | n/a |
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| Residue: | 492 |
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| Sequence: | MMSKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVP
KKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEG
LEFFLGWGSLESKNVVNVRESADPASAVKERLETENILLASGSWPHMPNIPGIEHCISSN
EAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELT
KQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNA
GVMIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHT
RVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHNISGSKYKTFVAKIITNHS
DGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVK
GEKMEKPSEASL
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| BDBM50280881 |
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| n/a |
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| Name | BDBM50280881 |
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| Synonyms: | (2-(2-Benzyloxycarbonylamino-2-{[(3-dimethylamino-propylcarbamoyl)-methyl]-carbamoyl}-ethylsulfanyl)-1-{[(3-dimethylamino-propylcarbamoyl)-methyl]-carbamoyl}-ethyl)-carbamic acid benzyl ester | CHEMBL302322 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H54N8O8S |
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| Mol. Mass. | 758.928 |
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| SMILES | CN(C)CCCNC(=O)CNC(=O)C(CSCC(NC(=O)OCc1ccccc1)C(=O)NCC(=O)NCCCN(C)C)NC(=O)OCc1ccccc1 |
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| Structure | 
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