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TargetEndothelin receptor ET-A
LigandBDBM50280989
Substrate/Competitorn/a
Meas. Tech.ChEBML_65809
IC50 16±n/a nM
Citation Mugrage BMoliterni JRobinson LWebb RLShetty SSLipson KEChin MHNeale RCioffi C CGS 27830, a potent nonpeptide endothelin receptor antagonist Bioorg Med Chem Lett 3:2099-2104 (1993)    Article
More Info.:Get all data from this article,  Assay Method
 
Endothelin receptor ET-A
Name:Endothelin receptor ET-A
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:48707.29
Organism:Sus scrofa
Description:ChEMBL_65803
Residue:427
Sequence:
METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50280989
n/a
NameBDBM50280989
Synonyms:2,6-dimethyl-5-methyloxycarbonyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic anhydride | CGS-27830 | CHEMBL67074
TypeSmall organic molecule
Emp. Form.C32H30N4O11
Mol. Mass.646.6008
SMILESCOC(=O)C1[C@@H](C(C(=O)OC(=[OH+])C2=C(C)N=C(C)C([C@H]2c2cccc(c2)[N+]([O-])=O)=C([O-])OC)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |w:29.31,c:12,37,t:15,34|
Structure
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