Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50281589 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_144795 |
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Ki | 16±n/a nM |
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Citation | Angelastro, MR; Bey, P; Mehdi, S; Janusz, MJ; Peet, NP Janus compounds: dual inhibitors of proteinases Bioorg Med Chem Lett3:525-530 (1993) Article |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50281589 |
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n/a |
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Name | BDBM50281589 |
Synonyms: | 5N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)-1-[3-methyl-2-{4-[2-methyl-1-[5-(3,3,4,4,4-pentafluoro-1-isopropyl-2-oxobutylcarbamoyl)-(5S)-dihydro-1H-1-pyrrolylcarbonyl]-(1S)-propylcarbamoyl]phenylcarboxamido}-(2R)-butanoyl]-(5R)-dihydro-1 | CHEMBL422675 |
Type | Small organic molecule |
Emp. Form. | C45H54F8N6O8 |
Mol. Mass. | 958.9329 |
SMILES | CC(C)[C@@H](NC(=O)c1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NC(C(C)C)C(=O)C(F)(F)C(F)(F)F)C(=O)N1CCC[C@@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)F |
Structure |
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