| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gastrin/cholecystokinin type B receptor |
|---|
| Ligand | BDBM50060321 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_47973 |
|---|
| pH | 6.5±n/a |
|---|
| IC50 | 3700±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Howbert, JJ; Lobb, KL; Britton, TC; Mason, NR; Bruns, RF Diphenylpyrazolidinone and benzodiazepine cholecystokinin antagonists: A case of convergent evolution in medicinal chemistry Bioorg Med Chem Lett3:875-880 (1993) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gastrin/cholecystokinin type B receptor |
|---|
| Name: | Gastrin/cholecystokinin type B receptor |
|---|
| Synonyms: | CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 48445.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Stable expression of human CCK-2 receptors in HEK 293 cells. |
|---|
| Residue: | 447 |
|---|
| Sequence: | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
|
|
|
|---|
| BDBM50060321 |
|---|
| n/a |
|---|
| Name | BDBM50060321 |
|---|
| Synonyms: | 1H-Indole-2-carboxylic acid ((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide | 1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide | CCK antagonist synthetic 19 | CHEMBL419764 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H20N4O2 |
|---|
| Mol. Mass. | 408.4519 |
|---|
| SMILES | CN1c2ccccc2C(=N[C@@H](NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1 |c:9| |
|---|
| Structure | 
|
|---|
Search and Browse
