| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50281767 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_142867 |
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| Ki | 0.300000±n/a nM |
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| Citation |  Emonds-Alt, X; Proietto, V; Broeck, DV; Vilain, P; Advenier, C; Neliat, G; Fur, GL; Brelère, JC Pharmacological profile and chemical synthesis of SR 48968, a non-peptide antagonist of the neurokinin A (NK2) receptor Bioorg Med Chem Lett3:925-930 (1993) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK-2 receptor | NK-2R | NK2R_RAT | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | SKR | Substance-K receptor | Tac2r | Tachykinin receptor 2 | Tacr2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43868.63 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Neurokinin NK2 TACR2 Murine::P16610 |
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| Residue: | 390 |
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| Sequence: | MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILA
HERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATK
CVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVPRHQAHGANLR
HLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMT
GDMTHSEATNGQVGSPQDGEPAGPICKAQA
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| BDBM50281767 |
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| n/a |
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| Name | BDBM50281767 |
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| Synonyms: | Acetic acid 1-{3-(3,4-dichloro-phenyl)-4-[ethyl-(thiophene-2-carbonyl)-amino]-butyl}-4-phenyl-piperidin-4-yl ester | CHEMBL368995 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H34Cl2N2O3S |
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| Mol. Mass. | 573.574 |
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| SMILES | CCN(CC(CCN1CCC(CC1)(OC(C)=O)c1ccccc1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 |
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| Structure | 
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