Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50282003 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_162611 |
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IC50 | 30±n/a nM |
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Citation | Holmes, DS; Bethell, RC; Hann, MM; Kitchin, J; Starkey, ID; Storer, R The design and synthesis of novel hydroxyproline inhibitors of HIV-1 proteinase Bioorg Med Chem Lett3:1485-1491 (1993) Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50282003 |
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n/a |
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Name | BDBM50282003 |
Synonyms: | (2R,4S)-2-((R)-Benzylcarbamoyl-phenylacetylamino-methyl)-5,5-dimethyl-thiazolidine-4-carboxylic acid ((S)-5-tert-butylcarbamoyl-3-hydroxy-1-isobutyl-pyrrolidin-3-ylmethyl)-amide | CHEMBL289409 |
Type | Small organic molecule |
Emp. Form. | C37H54N6O5S |
Mol. Mass. | 694.927 |
SMILES | CC(C)CN1CC(O)(CNC(=O)[C@@H]2N[C@H](SC2(C)C)[C@H](NC(=O)Cc2ccccc2)C(=O)NCc2ccccc2)C[C@H]1C(=O)NC(C)(C)C |
Structure |
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