| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor B |
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| Ligand | BDBM50282363 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_34831 (CHEMBL648765) |
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| IC50 | 0.16±n/a nM |
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| Citation |  Weinstock, J; Hill, DT; Keenan, RM; Franz, RG; Gaitanopoulos, DE; Girard, GR; Eggleston, DS; Aiyar, N; Griffin, E; Ohlstein, E; Brooks, DP; Gellai, M; Frederickson, TA; Weidley, EF; Edwards, RM A potent long-acting imidazole-5-acrylic acid angiotensin II AT-1 receptor antagonist Bioorg Med Chem Lett4:23-28 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor B |
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| Name: | Type-1 angiotensin II receptor B |
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| Synonyms: | AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40929.44 |
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| Organism: | RAT |
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| Description: | Angiotensin II AT1B 0 RAT::P29089 |
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| Residue: | 359 |
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| Sequence: | MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
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| BDBM50282363 |
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| n/a |
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| Name | BDBM50282363 |
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| Synonyms: | 4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-2,3-dichloro-benzoic acid | CHEMBL317343 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22Cl2N2O4S |
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| Mol. Mass. | 493.403 |
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| SMILES | CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(C(O)=O)c(Cl)c1Cl |
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| Structure | 
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