Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50282534 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_79799 (CHEMBL696059) |
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Ki | 8±n/a nM |
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Citation | Dorsselaer, VV; Schirlin, D; Tarnus, C; Taylor, DL; Tyms, AS; Weber, F; Baltzer, S; Remy, JM; Brennan, T; Janowick, D Increased antiviral activity of HIV protease inhibitors of the difluorostatone type bearing (R)-valinol derivatives as novel c-termini Bioorg Med Chem Lett4:1213-1218 (1994) Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50282534 |
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n/a |
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Name | BDBM50282534 |
Synonyms: | CHEMBL21095 | {(S)-1-[1-(4-Benzyloxy-benzyl)-3-((R)-1-benzyloxymethyl-2-methyl-propylcarbamoyl)-3,3-difluoro-2-oxo-propylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester |
Type | Small organic molecule |
Emp. Form. | C43H49F2N3O7 |
Mol. Mass. | 757.8619 |
SMILES | CC(C)[C@H](COCc1ccccc1)NC(=O)C(F)(F)C(=O)C(Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C |
Structure |
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